Week 1 of the 2022 NFL season was a thriller that featured some wild upsets. The Chicago Bears took down the San Francisco 49ers, the New York Giants pulled off an incredible comeback against the Tennessee Titans, and Russell Wilson lost in his return to Seattle. Expect even more madness in Week 2, especially because of some key injuries.
Thankfully, the experts at CBS Sports and SportsLine have you covered to guide you through this weekend's slate. Each week, we'll collect all of the best picks and gambling content from CBSSports.com and SportsLine in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more.
All NFL odds via Caesars Sportsbook.
Which picks can you make with confidence in Week 2? And which Super Bowl contender goes down hard? Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up more than$7,500 for $100 players on top-ratedNFL pickssince its inception.
Seattle Seahawks at San Francisco 49ers
Time:Sunday, 4:05 p.m. ET (Fox), stream on fuboTV (try for free)
Open:49ers -7.5, O/U 44.5
"Pretty shocking to see how this line moved based off the respective Week 1 results from these NFC West rivals. Seattle looked great against theBroncos, stealing a win from Russ and Denver. The49erssuffered an eyebrow-raising loss in Chicago, albeit one that took place in a rarely seen monsoon. The weather conditions definitely warrant givingTrey Lanceand the offense a pass, although it didn't exactly stopJustin Fieldsand theBearsfrom finding points in the second half. Pete Carroll has had a lot of success against San Francisco in the past half decade, and theSeahawkslook legitimately formidable."
New Seahawks fan Will Brinson likes Seattle to keep it close this week, and go 2-0 ATS. For his gambling breakdown of every game in Week 2, clickhere.
 Pete Prisco |  Jason La Canfora |  Will Brinson |  Jared Dubin |  Ryan Wilson |  John Breech |  Dave Richard |  Jamey Eisenberg | |
|---|---|---|---|---|---|---|---|---|
| Seahawks at 49ers (-9.5) | Seahawks | Seahawks | 49ers | Seahawks | Seahawks | Seahawks | 49ers | Seahawks |
Atlanta Falcons at Los Angeles Rams
Time:Sunday, 4:05 p.m. ET (Fox), stream on fuboTV (try for free)
Open:Rams -13.5, O/U 50
"TheRamswill have been rested for 10 days after a terrible showing against theBills. Sean McVay is too good a coach for that loss to linger. TheFalconsplayed well in losing to theSaintsin a game they probably should have won. This is a long trip against a good team that will be focused. Rams take it big."
CBS Sports Senior NFL Columnist Pete Prisco is taking the Rams to rebound after their Week 1 loss. Check out his breakdown of every game in Week 2,here.
Pete Prisco | Jason La Canfora | Will Brinson | Jared Dubin | Ryan Wilson | John Breech | Dave Richard | Jamey Eisenberg | |
|---|---|---|---|---|---|---|---|---|
| Falcons at Rams (-10.5) | Rams | Rams | Rams | Falcons | Falcons | Rams | Falcons | Rams |
Arizona Cardinals at Las Vegas Raiders
Time:Sunday, 4:25 p.m. ET (CBS), stream on Paramount+ (click here)
Open:Raiders -2.5, O/U 50.5
"Las Vegas didn't post nearly as many points as hoped, but moved the ball up and down the field on what might be a qualityChargersdefense. Five sacks and three picks set them back, but theCardinalsdefense looked flaccid and unimposing. TheRaidersaveraged 7.33 yards per first-down play last week. It was pretty impressive, and Carr will learn not to favor Adams quite as much. The Raiders will generate pressure against a suspect Cardinals offensive line, and I could see thisChandler Jonesrevenge game going as well as theKhalil Mackrevenge game went against the Raiders last week. Vegas can run the ball, too. The Cardinals are still a little beat up, and I don't get a good vibe from them. Give me Raiders over 3.5 touchdowns for +100 as well."
SportsLine NFL Insider Jason La Canfora envisions the Raiders bouncing back this Sunday. To view his other top Week 2 plays,head on over to SportsLine.
Pete Prisco | Jason La Canfora | Will Brinson | Jared Dubin | Ryan Wilson | John Breech | Dave Richard | Jamey Eisenberg | |
|---|---|---|---|---|---|---|---|---|
| Cardinals at Raiders (-5.5) | Raiders | Raiders | Raiders | Raiders | Raiders | Raiders | Cardinals | Raiders |
Cincinnati Bengals at Dallas Cowboys
Time:Sunday, 4:25 p.m. ET (CBS), stream on Paramount+ (click here)
Open:Cowboys -1, O/U 52
"Cincinnati was minus-five in turnovers and still would have beaten theSteelersif not for placekicking disasters. TheBengalshad 32 first downs. Dallas, on the other hand, looked discombobulated even beforeDak Prescott'sinjury. Plus, theCowboyslost left guardConnor McGovernand safetyJayron Kearseto multiple-week injuries. Bengals No. 2 wideoutTee Higgins(concussion) is on track to play after getting in a limited practice Wednesday. BackJoe Burrowto bounce back from that four-interception debacle as Cincy covers a short teaser number."
NFL gambling expert Larry Hartstein, who entered 2022 up more than 37 units on his NFL side picks for SportsLine, has officially filed his teaser picks for Week 2. As you can see, he likes bringing down the Bengals from -7.5 to -1.5. For his other teaser legs,head on over to SportsLine.
Pete Prisco | Jason La Canfora | Will Brinson | Jared Dubin | Ryan Wilson | John Breech | Dave Richard | Jamey Eisenberg | |
|---|---|---|---|---|---|---|---|---|
| Bengals (-7.5) at Cowboys | Cowboys | Bengals | Bengals | Bengals | Bengals | Bengals | Bengals | Cowboys |
Houston Texans at Denver Broncos
Time:Sunday, 4:25 p.m. ET (CBS), stream on Paramount+ (click here)
Open:Broncos -10.5, O/U 42
TheBroncossuffered an upset loss to theSeahawksin Week 1, but with that emotional matchup out of the way,Russell Wilsonand Co. can now settle in and focus on becoming the AFC contender many view them as. At home in Week 2 vs. an inferior squad, we could see fireworks from the Broncos offense. Denver could be a good survivor pick this week if you didn't fall into the trap of picking them Week 1.
For more survivor picks and tips, check out R.J. White's weekly breakdown,here.
Pete Prisco | Jason La Canfora | Will Brinson | Jared Dubin | Ryan Wilson | John Breech | Dave Richard | Jamey Eisenberg | |
|---|---|---|---|---|---|---|---|---|
| Texans at Broncos (-10) | Texans | Texans | Broncos | Broncos | Broncos | Texans | Texans | Texans |
Chicago Bears at Green Bay Packers
Time:Sunday, 8:20 p.m. ET (NBC), stream on fuboTV (try for free)
Open:Packers -8.5, O/U 44
Before you make any Bears vs. Packers picks or any other NFL predictions, you need to see which side NFL expert R.J. White is on. White, a fantasy and gambling editor for CBS Sports, consistently crushes as SportsLine's No. 1 NFL expert in picks against the spread, and went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. He's also gone a whopping 51-17-1 on his NFL picks involving the Packers, meaning he's well-qualified for this selection.
We can tell you he's leaning Over the total, but for his official against-the-spread pick, you'll have to head over to SportsLine.
Pete Prisco | Jason La Canfora | Will Brinson | Jared Dubin | Ryan Wilson | John Breech | Dave Richard | Jamey Eisenberg | |
|---|---|---|---|---|---|---|---|---|
| Bears at Packers (-10) | Packers | Bears | Packers | Packers | Packers | Bears | Bears | Packers |
Tennessee Titans at Buffalo Bills
Time:Monday, 7:15 p.m. ET (ESPN), stream on fuboTV (try for free)
Open:Bills -7.5, O/U 52
A former lead writer for Covers and The Linemakers, Larry Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Entering the 2022 NFL season, he is 427-344 all-time on NFL sides (plus $3,764 for $100 players), including 394-330 against the spread. Hartstein went 68-50 ATS (58 percent) and 8-3 on money line plays last season for a profit of $1,552. Anybody who has been following him is way up. In addition, Hartstein has gone 23-12-1 on his last 36 picks involving theTitans, returning $1,007.
We can tell you he's leaning Over the total, but to see his against-the-spread pick,head on over to SportsLine.
| Titans at Bills (-10) |
Minnesota Vikings at Philadelphia Eagles
Time:Monday, 8:30 p.m. ET (ABC), stream on fuboTV (try for free)
Open:Eagles -2.5, O/U 48
SportsLine expert Emory Hunt is the founder and CEO of Football Gameplan, which has been supplying analysis of all levels of football since 2007. He is a former running back at Louisiana-Lafayette and knows the game from a player's perspective. Hunt has gone 35-20-1 on his last 56 picks involving the Eagles, returning $1,281. Anyone who has followed him is way up.
We can tell you he's leaning Over the total, but for his official against-the-spread pick, head over to SportsLine.
| Vikings at Eagles (-2.5) |
